I have the exact same problem. Been using itunes for years and never had this happen. The songs that happens with me is Dee Lite - Groove Is In The Heart (Radio Edit). I have several copies of that track from various albums I have downloaded, and every single one of them crashes itunes.
I've downloaded the single version, it crashes.
And when I say crashes itunes, it crashes windows, laptop etc. Only way to resolve is to restart laptop. HardDrive goes crazy, like it's really really trying to load the track and just freezes up the whole system. I've tried deleting the tracks, every single copy, but that too freezes my laptop.
I've loaded the tracks into Virtual DJ and Virtual DJ only loads the first 5 seconds of the track, harddrive goes crazy, and then virtualDJ closes.
I've yet to find other files that do the same, but I'm sure I will. This happened to me tonight during a party, and it was very embarrassing having to reboot the laptop 3 times. I even had to do a system restore, defrag and 'sort my library', to no avail. I can assure everyone who reads this that the track played like a dream, over and over again 'prior' to this latest i-tunes update. Something has went wrong somewhere.
I've downloaded the track once again legitimately from Amazon MP3 now, and imported it into itunes, and it plays absolutely fine.
EDIT: I took to the gauntlet, and tried all the 'other' files named Groove Is In The Heart, and the only file that, at the moment, has a problem is the version that comes with Ministry Of Sound - 90's Groove.
All the other versions work fine since downloading the single version from Amazon.
Windows 7 64x. Itunes 22.214.171.124