Also it happens without the MBOX 2 connected, which is USB audio interface by the way, and with just a Seagate external USB 3 Drive connected, which I use for backing up and has worked fine without these sleep issues up to 10.8.4.
So it is like this...you put the computer to sleep, it goes to sleep, external drive spins off, after a few seconds external drive spins on again for no reason, display stays in sleep, but not rest of the system, as when you wake up a good indication to see whether it has woken up from deep sleep or just display sleep is that if you had wifi on and connected, when it wakes up now it is always connected to wifi, whereas when normally the imac wakes up from deep sleep the wifi connection(just the connection not the wifi interface) is off and is looking for it and connecting to it after you have woken it up. Something totally going wrong with the power management since 10.8.5, no doubt. Ι initially had installed 108.5 from the software update window, done the combo update on top now, and still no change in this behaviour. Strange that it let's me install the 10.8.5 combo, as before, if you had installed the update, it would not let you do it again...Not sure about what this is...
I had different but still sleep issues with an imac late 2009 i7 27inch, after a certain update in Snow Leopard, where again I had done the update through the software update window, instead of downloading the combo one...back then it was that it wouldn't actually go to deep sleep, just display sleep.
It is so frustrating that this happens. The biggest issue is that if you leave the computer supposedly at this sleep for a long time it does not wake up from the mouse or elsewhere...!!!!
And another update, removing the Seagate MyBackup(USB 3) or whatever it is called, putting the computer to sleep, and waking up, it does actually behave as it should, it wakes up and the wifi is looking for the connection and connects after a few seconds, it is not connected as when you have a USB device connected(the MBOX 2 or the Seagate external USB 3 drive in my case) which it seems wakes up the computer from deep sleep(which means it is on and the wifi connects in the background)immediately after a few moments you put it to sleep(observation is that MBOX keeps on going on and off sleep as led's go off and on at regular intervals and the same seems to happen with the external drive....).
The cure...in Snow Leopard with the sleep problems after an update, was to re-install leopard and do the combo update, meaning re-installing the whole system, which is quite a pain in the back side. I hope this is not the case in Mountain Lion otherwise we should be compensated for Apple ruining our system and organisation. The only cure I see for the minute and I am not sure if it will work is to revert to an earlier Time-Machine Backup which was made when the system was still in 10.8.4. And if this works, I will not do the 10.8.5 stnadalone or combo update until Apple start becoming serious with us, and not mess with our work and computers which they sold to us as the perfect machines...
On another note my 27" i7 2012 imac had also these backlight uniformity problems, where part of the screen is slightly darker(on the right hand side, nothing major but noticeable as the same colour has a different hue in the brighetr area of the screen) so I am quite fed up with this drop in QC at Apple, not only in hardware but in software...I am currently waiting for a replacement, but this is nothing to do with this update.
I seriously hope that they release 10.8.6 soon and that it will solve these issues which people who installed 10.8.5 already are experiencing. In fact even their suggestion, if it will be one, let's see, for people to consider going to an earlier backup where the system worked fine(what I am considering to do now), will be unreasonable and undermine their ability to create problem free updates and software which affect basic functions of the system such as sleep, and they will have no excuse, as it is not us who did something wrong to our system, it is their update which they fed to our systems through their software update, and let's say as the ordinary mac user thought it would be good to do...so there is an element of fooling people there as well...What if someone just bought their mac recently and did not have a backup but had already set up(customised) their system to a signinicant degree before the 10.8.5 update? I believe that we should be covered and compensated for such things, as I have lost time and money dealing with these issues in the past.
Don't they properly test these updates, with all their fleet of different mac models, testing them with general peripherals connected to them, that people normally use, such as USB DEVICES, Audio Interfaces, External USB Drives? Come on they make billions for god's sake. We're spending 2 grand on a system that is touted as heaven on earth and it does many things brilliantly, but does fail on some, and what I really get is all these ridiculous issues every now and then which make me lose time and money, as I just want to have a system that sleeps and wakes properly!!!!!!! I AM NOT HAPPY, and it is Apple's Programmers which messed it up for me again...No bonuses this month please.