I seem to be having the exact same problem.
I'm using a mid 2011 mini with the 2.3 GHz i5 processor.
I just updated to 10.8.5 and now the sound output failed every
day or two. Now every few hours.I have to restart the computer
to get it back. I've tried changing imputs, swapping cables,
changing the settings in system preferrences.
Nothing works except a reboot. : (
In reply den.thedwrote:
When the sound stops working, go to: Applications > Utilities > open Audio MIDI setup > select Output > reselect the desired output source and/or fiddling around with the output format settings.
This problem could also be related to audio settings in GarageBand, Pro App's or any other third party audio software that you might be running.
If that doesn't help... then it won't hurt to:
1. Reset the SMC > Resetting the System Management Controller (SMC)
1. Shut down the computer.
2. Unplug the computer's power cord.
3. Wait fifteen seconds.
4. Attach the computer's power cord.
5. Wait five seconds, then press the power button to turn on the computer.
2. Zap the NVRAM PRAM > About NVRAM and PRAM
1. Shut down the computer.
2. Locate the following keys on the keyboard: Command, Option, P, and R. You will need to hold these keys down simultaneously in step 4.
3. Turn on the computer.
4. Press and hold the Command-Option-P-R keys. You must press this key combination before the gray screen appears.
5. Hold the keys down until the computer restarts and you hear the startup sound for the second time.
6. Release the keys.
This has not worked for me, but maybe it could help you.