My iMac: 27" i7, 1GB fusion drive, 780M, bought with 8GB, upgraded to 16GB.
I've had my iMac for about 2 months now. This is the first Mac desktop I've owned since I purchased a Mac Plus back in 1987, I've had exclusively laptops since 2000. I switched from laptop to desktop since Apple has pretty much abandoned the idea of the "Workstation" laptop. I use my iMac for gaming and photo editing/managing.
The iMac is about 2 months new, and I love it so far. The benefits of the fusion drive are immediately obvious. I wanted to try to "maximize" the Fusion drive by installing the apps I would use most often, first. Not sure if that really makes much of a difference, but overall access times are impressive. From hitting the power button to hitting the login icon is about 15-20 seconds. Amazing. My frequently used games and photo apps also load very quickly.
I went with the 780M primarily because of the GPU upgrade, the memory doesn't seem to make much of a difference yet, but from what I've read, the 4GB should be able to be much more of a benefit in the near future. I am running a secondary 2560x1540 display, making use of the inanely large desktop space to have multiple photo apps open at the same time.
I did upgrade the RAM to 16GB myself about 2 weeks ago. The difference wasn't immediately noticable. But after "loading up" the system with 5 different photo apps to setup a workflow destop, and working with both RAW and JPG images at the same time with multiple editors, there's a huge difference the speed of switching apps, and manipulating images. It wasn't exactly slow when I was running 8GB, but I can basically open every app I might need, at once, and switch seamlessly between them. I know that there are "issues" with how Mavericks handles memory, and it's insanely high use of RAM for file cache, so it's really hard to say how much real RAM I was using at the peak, but I never maxed it out, so I could have pushed it much farther, but I just ran out of "real world" apps to load up. So, 8GB is definitely useable, but 16GB is a monster.