You might not be able to disable the internal display but you can place it logically out of the way and darken it.
System Preferences > Displays > Arrangement
Drag the menu bar to the external display.
Drag the image of the internal display down so it is not next to the external display.
Put all of your desktop icons on the external display.
Adjust the brightness on the internal display to full dark.
When you disconnect the external display, Mac OS X will rearrange your desktop onto the the internal display and vice versa.
Think you will find that is less functional than using the internal display as a logical extension of the external one with your most used windows on the external display and others on the internal display.
I assume you have a separate keyboard and mouse for the external display.