Check the outgoing mail server setting. Make sure that your username and password are in there.
Settings>Mail, Contacts, Calendars>Your email account>Account>Outgoing mail server - tap the server name next to SMTP and check in the primary server and make sure your username and password are entered and correct - even if it says that the password is optional.
log on to your email providers website to ensure you know password. reset if you dont
go to settings-mail contact calanders- click affected account - scroll to bottom and delete the account
now go back to settings-mail contact calanders and add account. choose other if your email is not on list and add email. use the same info u loged into providers website with
iOS: Unable to send or receive email
Can’t Send Emails on iPad – Troubleshooting Steps
Setting up and troubleshooting Mail
Server does not allow relaying email error, fix
Why Does My iPad Say "Cannot Connect to Server"?
iOS: 'Mailbox Locked', account is in use on another device, or prompt to re-enter POP3 password
Configuration problems with IMAP e-mail on iOS with a non-standard SSL port.
Try this first - Reset the iPad by holding down on the Sleep and Home buttons at the same time for about 10-15 seconds until the Apple Logo appears - ignore the red slider - let go of the buttons. (This is equivalent to rebooting your computer.)
Or this - Delete the account in Mail and then set it up again. Settings->Mail, Contacts, Calendars -> Accounts Tap on the Account, then on the red button that says Remove Account.