A few random points,
You have a few additional Time Machine exclusions that will probably prevent you restoring a full OS if you ever need to do so. Is there much benefit to excluding /System /sbin /usr etc?
You main HD is 320GB with about 270GB used?
It's not a massive problem, but it looks like a spinning disk HD. These drives will decrease in performance as they get fuller (read & write speed falls as data reaches the center of the disk). Free up more disk space if you feel it is getting slower. Here are some links that show how speed tapers off… (some folks only believe graphs 🙂)
http://techreport.com/review/24561/seagate-laptop-thin-sshd-500gb-hybrid-drive-r eviewed/4
http://macperformanceguide.com/Storage-Drive-Toshiba-HGST-3TB.html
The FanControlDaemon startupitem is dubious
Too many Utilities: (are they even current?)
MacKeeper
AppTamer
Macaroni <-("have been discontinued and are now free" - How old is this?)
Sophos version 8 (isn't v9 the latest?)
[failed] com.hidden.startup.plist <- Did you know your "Antitheft tracker" is crashing?
com.rim.BBDaemon.plist <- Are you using blackberry devices with this Mac?
Lee Collins wrote:
Startup Items:
FanControlDaemon - Path: /Library/StartupItems/FanControlDaemon
Kernel Extensions:
com.sierrawireless.driver.SierraVSP (1.0.0)
com.Cycling74.driver.Soundflower (1.4.4)
net.telestream.driver.TelestreamAudio (1.0.5)
com.sophos.kext.sav (8.0.14)
Problem System Launch Agents:
[loaded] com.paragon.NTFS.auth.plist
Launch Daemons:
[loaded] com.adobe.fpsaud.plist
[loaded] com.adobe.SwitchBoard.plist
[loaded] com.adobe.versioncueCS3.plist
[loaded] com.atomicbird.macaroni.launchd.plist
[loaded] com.bjango.istatserver.plist
[loaded] com.carbonite.launchd.carbonitedaemon.plist
[loaded] com.ciscosystems.ciscoconnect.daemon.plist
[loaded] com.fitbit.galileod.plist
[loaded] com.google.keystone.daemon.plist
[loaded] com.livescribe.PenCommService.plist
[loaded] com.microsoft.office.licensing.helper.plist
[loaded] com.rim.BBDaemon.plist
[loaded] com.sophos.autoupdate.plist
[loaded] com.sophos.intercheck.plist
[loaded] com.sophos.notification.plist
[loaded] com.stclairsoft.AppTamerAgent.plist
Launch Agents:
[not loaded] com.adobe.AAM.Updater-1.0.plist
[loaded] com.adobe.AdobeCreativeCloud.plist
[loaded] com.carbonite.launchd.carbonitealerts.plist
[loaded] com.carbonite.launchd.carbonitestatus.plist
[loaded] com.flipvideo.FlipShare.AutoRun.plist
[loaded] com.google.keystone.agent.plist
[failed] com.hidden.startup.plist
[loaded] com.rim.BBLaunchAgent.plist
[loaded] com.seagate.SeagateStorageGauge.plist
[loaded] com.sierrawireless.SwitchTool.plist
[loaded] com.sophos.uiserver.plist
User Launch Agents:
[loaded] com.adobe.ARM.[...].plist
[loaded] com.adobe.ARM.[...].plist
[loaded] com.facebook.videochat.leecollins.plist
[loaded] com.microsoft.LaunchAgent.SyncServicesAgent.plist
[loaded] com.zeobit.MacKeeper.Helper.plist
User Login Items:
Jing
Dropbox
3rd Party Preference Panes:
Adobe Version Cue CS3
Carbonite
RCDefaultApp
Fan Control
Flash Player
Flip4Mac WMV
Java
Macaroni
MacFUSE
Paragon NTFS for Mac ® OS X
Perian
Internet Plug-ins:
AdobeAAMDetect.plugin
AdobePDFViewer.plugin
AdobePDFViewerNPAPI.plugin
AmazonMP3DownloaderPlugin.plugin
Default Browser.plugin
Flash Player.plugin
FlashPlayer-10.6.plugin
Flip4Mac WMV Plugin.plugin
GlancePlugIn.plugin
googletalkbrowserplugin.plugin
iPhotoPhotocast.plugin
JavaAppletPlugin.plugin
npgtpo3dautoplugin.plugin
o1dbrowserplugin.plugin
OfficeLiveBrowserPlugin.plugin
QuickTime Plugin.plugin
SharePointBrowserPlugin.plugin
Silverlight.plugin
wkDimdimControl.plugin
User Internet Plug-ins:
CitrixOnlineWebDeploymentPlugin.plugin
Red items are loaded at the system level
Blue items are loaded at the user level
All the usual caveats apply, backup before you modify the system, delete the items (or move them to another disk or folder if you are worried about deleting the wrong thing) but ensure the originals are gone or updated.
Use the Finders "Go menu > Go to Folder…" to open the hidden ~/Library (your users library).
Reboot for the system changes to take effect.
How to find updates:
The critical launchd jobs & kernel extensions use reverse domain notation e.g.
com.logmein.hamachi.plist means look at http://logmein.com for updates (if you don't recognize it removing it may be appropriate)
In short: You want to try to update or remove all the system level items.
Startup Items: Stored in /Library/StartupItems/
Startup Items have been discontinued by Apple since Mac OS 10.4. They are responsible for making changes at a system level. Remove them all or spend time ensuring ALL related software is up to date. You need a very good reason to have anything installed in here. The developers are ignoring Apple guidelines by installing these - not a good sign.
Kernel Extensions: Stored in /Library/Extensions/
Kernel Extensions also load third party code, but they insert it into the 'core' of the OS. These can be safe, however you must ensure the related tools or apps are up to date, otherwise the system is basically built upon quicksand. Remove them all & see if the OS works better.
Launchd jobs: several types
LaunchAgents - Stored in /Library/LaunchAgents
LaunchDaemons - Stored in /Library/LaunchDaemons
User LaunchAgents - Stored in ~/Library/LaunchAgents
These are all background jobs, they are not necessarily bad, but if they are loading old code it could be doing untold damage to the performance & stability of the entire OS. Focus on the System level jobs (the ones inside /Library - the system level) also remove ['failed'] jobs.
EtreCheck gives a status on launchd jobs…
[loaded] - a running job
[not loaded] - jobs that are set not to run, basically harmless, remove them unless you plan to use the associated software (if it is up to date)
[failed] - jobs in a crashed or unknown state, it could be forking processes or using all the system resources, remove these.
User login items:
Applications and helpers that are managed inside 'Systems Preferences > Users and groups > Login Items tab'.
These are loaded at the 'User level', consider removing all of them whilst you troubleshoot. When you decide to re-add them ensure the software is up to date.
3rd Party Preference Panes: & Internet Plug-ins:
/Library/PreferencePanes/ and ~/Library/PreferencePanes/
/Library/Internet Plug-Ins/ and ~/Library/Internet Plug-Ins/
Once again these items all must be up to date, or remove them from your system. If the prefpanes manage additional software use the uninstaller or see the developers site for uninstall instructions. You can also right click to remove 3rd party preference panes in System preferences
Read the list of Internet plug-ins carefully, there are often duplicate Flash player versions that won't help stability, it's just wasted space too.
Don't forget to also update Safari's extensions in it's preferences (if you have any).
Re-run EtreCheck after cleaning up to see if items have returned (some apps will reload the background jobs when re-opened, so either update or remove the software).
Hope that isn't too daunting, the OS should be better if there are less old items running at the system level.