Good News: I can confirm that OS X 10.9.2 fixes the issue with the Fusion Drive and MBox Mini (and possibly other USB Audio devices).
My Hardware:
27" iMac, latest version, 3.5 GHz i7
3TB Fusion Drive
8 GB RAM
Drobo 5D hooked up via Thunderbolt
2 24" LED Cinema displays, one directly connected to Thunderbolt, one chained off the Drobo's second Thunderbolt port
MBox Mini connected via USB on Cinema Display that is chained off the Drobo
Logic Pro X 10.0.6
Previous symptoms:
Audio drop outs after a few minutes in all sound related applications
Audio degradation in Logic
Both iTunes and Spotify Apps could (and often) froze machine (no mouse or trackpad or keyboard input until hard restart)
None of these issues occured when switching all audio to go through iMac's built in speakers.
Last night I installed the Mavericks 10.9.2 Combo Update (13C32) available right now only to developers, but you can find it, it's out there.
Everything works just fine now.
Stress test:
Before I went to bed I put a large Spotify playlist on shuffle and repeat, did the same for an iTunes playlist, and looped a 32 track Logic project all at once (yes, this sounded horrible!) and turned the volume down on my MBox Pro. When I woke up and turned the volume up on my MBox Mini, all was still playing through my Event 20/20 speakers. I have worked all day today in Logic and it works great.
I thought I was going to have to send my iMac back for one with just an SSD or perform the Fusion Drive split that people were talking about, but all is well.
Hopefully this update will be released soon for everyone.
Hope this helps. I personally was heartbroken for a couple days as my new machine was pretty much useless and I had already given my awesome early 2011 quad-core MacBook Pro to my brother.
Keep the faith 🙂