You can use Radeon 7950, 7970 and R9 280x with "old" Mac Pros. They are supported in Mavericks. You could even go for dual Radeon 7770, although no boot screen.
For the 7950, 7970 and R9 280x to work 100% you will have to flash them with EFI for Mac, that will give you bootscreen, as far as I know, although they will work just fine without EFI flash. Just no boot screen.
AND: to get full 5GT linkspeed you will have to remove a very small resistor on GPU.
The MacVidCards come flashed and with the resistor removed. So you pay the guy for that service and painless plug and play.
The 7970 and 280x require 1 x 6 pin and 1 x 8 pin power adapter. A lot of people say that it works fine with a 6 x 8 pin adapter and the Motherboard won't get fried, but to make shure you could go for 2 x SATA to 1 x 6 pin power dapter to get power from those ports for the 6 pin and then get a 2 x 6 pin to 1 x 8 pin adapter.
This way you can make shure that there's enough power for these cards, but you will lose 2 x SATA connectors.
I run a flashed reference design MSI gtx 680, which needs 2 x 6 pin and runs without any flaws.
Visit
http://forums.macrumors.com/showthread.php?t=1547340
and netkas.org to find out more.