I need to integrate a video source, with an HTML source, and pull data from a database. It's similar to what InDesign or Dreamweaver or Keynote might do, but I've seen specialized applications available for Windows (InfoCaster at infocaster.tv is one) and I'm hoping to find an OS X application.
As for resolution: 1920x1080 vertically oriented. (Which InfoCaster doesn't fully support.)