Are you crazy? In iTunes-speak, "Sync" means "erase!" Sync is safe only If your iTunes library and iPhone can have the exact same contents. But if you have had any complications at all, using Sync endangers all your files.
- I had to rebuild my iTunes library after switching to a new computer, so I had hundreds of tracks on my iPod that weren't in my library. Using Sync erased all of them!
- I have multiple old devices. I put music on the iPod, career-related podcasts on an iPhone 3, books on tape on an iPod mini (which has comparatively little memory, and so on. The iTunes Library does not remember which tracks go on which device. Using Sync destroys that organization.
- I have thousands of tracks in iTunes on my computer. Even if I used only one device (e.g., my iPhone 5), only a fraction of them will fit on the device.
- If I want to transfer a single track to my iPhone, using Sync can waste a huge chunk of my time by indiscriminately deleting and transferring an entire library.
Even Microsoft couldn't have come up with a file-organizing system worse than iTunes. It's not so great for finding what you want in the iTunes Store, either. And Sync can burn a lot of time and money that you'll never get back.