error OSStatus -54

Not sure what the specifc code means but...

There are 9 different versions of iPhoto and they run on 9 different versions of the Operating System. The tricks and tips for dealing with issues vary depending on the version of iPhoto and the version of the OS. So to get help you need to give as much information as you can. Include things like:

- What version of iPhoto.

- What version of the Operating System.

- Details. As full a description of the problem as you can. For example, if you have a problem with exporting, then explain by describing how you are trying to export, and so on.

- History: Is this going on long? Has anything been installed or deleted? - Are there error messages?

- What steps have you tried already to solve the issue.

- Anything unusual about your set up? Or how you use iPhoto?

Anything else you can think of that might help someone understand the problem you have.

Many pictures are gone

Sounds like you have a damaged Library, and as you're unclear except to say this has been going on a long time, the best I can suggest to you is restore from your back up.