How do I sync Iphone to personal computer and calendar / contacts to separate work computer?

Here's the deal: By design, iPhone will sync iTunes content...apps, music, pics, etc...with ONE computer at a time. While it is possible to sync contacts/calendars with a different computer, Apple specifically warns against doing so, warning this "can" lead to data corruption, loss or both". Most users who try to sync contacts/calendars with a different computer end up regretting it.

Your mileage may vary.

If you want to do so, make sure EVERYTHING but Contacts/Calendars is turned off/de-selected on your work computer. On your home computer, make sure Contacts/Calendars are turned off.

Good luck.

This support document will provide some of the information that wjosten is talking about, concerning issues and data loss that can occur. http://support.apple.com/kb/TS1474