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Mar 16, 2014 4:19 PM in response to Gloria 2014by dominic23,Press command + option + esc keys together at the same time. Wait.
When Force Quit window appears, select the Mail, if not already.
Press Force Quit button at the bottom of the window.
Wait. Mail will quit.
If this does not help, press the power button for 7 or more seconds.
Computer will shut down.
Restart.
http://support.apple.com/kb/HT3411
Finder > Applications
Can you start Mail from the Application folder?