i got my credit card statment and i have big charges paid to i tune i dont know about it the only app i use and i pay it through you is keku and usually it is about 25$ a month now i have four handreds dollars charged can some body tell me how

First, log into your iTunes Store account and see if the purchases are reflected in the Purchase History.

http://support.apple.com/kb/HT2727

If they are and you're sure you or someone you know didn't make the purchase, immediately change the password to your iTunes Store account, making sure it's not something easily guessed or looked up. Then go here:

http://www.apple.com/support/itunes/contact/

and follow the instructions to report the issue to the iTunes Store.

If the charges are not reflected in the Purchase History, then it's most likely a fraudulent charge to your credit card directly rather than an unauthorized purchase through your iTunes Store account and it will be up to your bank to handle.

Regards.