I want to address the compatibility of 4k UHD displays and the Sapphire Radeon 7950 Mac Edition definitively here.
With this card, your Mac will support 3840 x 1440 over a DisplayPort 1.1a connection.
In other words, your monitor needs to be configured to use DisplayPort 1.1a if you want to boot a "4k UHD" display with the Sapphire card. Some monitors do not support this protocol out of the box, so check with the manufacturer for compatibility before you order a new display.
With the Sapphire card, trying to boot a single 4k monitor using DisplayPort 1.2 will yield a black screen at startup and you will unable to boot your system with that configuration.
Vertical resolution will be limited to 30 Hz with any "4k" display using DisplayPort or HDMI. Interestingly, some monitor DVI-D implementations allow for 30 Hz at 3840 x 1440, which goes beyond the DVI specification's max resolution. The trade-off is reduced color bit-depth (# bits per pixel) compared to HDMI. DisplayPort connections have the highest bit-depth, overall.
About Scaling:
You can scale the full resolution of the 4k display to 2560 x 1440 or something else; however, the card will send the full 4k UHD signal through the DisplayPort connection, no matter the resolution you choose. For example, a standard 1080p resolution will use the DisplayPort 1.1a's entire bandwidth, which gives an effective bandwidth of 3840 x 1440 pixels.
The only benefit you get from scaling the display is that of readability.
There are two factors that limit the card's performance:
1. the card's firmware
2. the Mac's drivers
BOTH need to support your display.
At boot time, the card supports only DP 1.1a. I've not found any firmware revisions that allow the card to use DP 1.2 at boot time.
Apple's Radeon drivers support DP 1.2, but only after the system has booted and Apple's driver has taken over. You can use a lower-resolution monitor as your "boot" monitor and get DP 1.2 through the 4k monitor with Apple's drivers with a two-monitor configuration. Some monitors will show 60 Hz, but most will be stuck at 30 Hz. This restriction is due to the number of bit-depth in a "millions of colors" versus a "billions of colors" signal.
This card does not support "true 4k" displays ( > 4000 pixels horizontal) because there is not enough bandwidth in the DP 1.1a connection to render billions of colors at "true 4k." Some monitors get around this by using two DP 1.1a connectors for a single monitor, thus doubling the bandwidth from the card to the display. I have no idea how well that configuration works, but I would expect some screen tearing during heavy use.
Fun Fact: The "UHD" tag primarily refers to wide color gamut, not screen resolution.