MacBook Pro Hardrive storage double the size it should be
I'm having a problem with my Macbook Pro hard drive in that it is using more space than it should. I have a 750GB hard drive and now only have 20GB of space left. Having ran an OS X Lion compatible version of OmniDiskSweeper it confirms that really the hard drive should only be 412.8GB full (but then doesn't show me where the remaining 319GB is coming from). The additional space-take-up is also categorised as part of 'Other' when viewing the storage tab on 'About This Mac'.
I have already had a browse through various forums but haven't really found anything that has been particularly helpful. I've tried disabling time machine local backups (as I back up to an external hard drive) from instructions at this link: http://osxdaily.com/2011/09/28/disable-time-machine-local-backups-in-mac-os-x-li on/ but that hasn't solved the issue. Software such as Disk Inventory and WhatSize have been no help either.
I'm running Mac OS X Lion 10.7.5 on a 15-Inch Early 2011 MacBook Pro and have included as much info as possible in the attached screen shot. Any help would be much appreciated in my mission to reclaim the other half of my hard drive!