Definitely let them go.
First major 10.10.0 bug I tested in 10.10.1 is still there.
If you have an external disk that is dismounted when Time Machine runs, next occasion that Time Machine runs and the disk is mounted - Time Machine uses total space on that disk as part of the requirement.
Why is this important - because it vastly overstates what is needed and may unnecessarily delete backups.
Example - Calculated c47GB (wrong) but only backed up c110KB, (correct) so may have deleted anything up to 47GB of backups that it shouldn't.
1. Do Time Machine Backup
2. Dismounted ScratchUse
3. Do Time Machine Backup
4. Mounted ScratchUse
5. Do Time Machine Backup
This is the output from item 5.
17/11/2014 19:49:25.153 com.apple.backupd[653]: Starting manual backup
17/11/2014 19:49:25.166 com.apple.backupd[653]: Backing up to /dev/disk4s2: /Volumes/Time Machine Backup/Backups.backupdb
17/11/2014 19:49:26.109 com.apple.backupd[653]: Will copy (Zero KB) from ScratchUse
17/11/2014 19:49:26.112 com.apple.backupd[653]: Will copy (110 KB) from Macintosh HD
17/11/2014 19:49:26.112 com.apple.backupd[653]: Will copy (Zero KB) from Photo Masters Vol 3
17/11/2014 19:49:26.113 com.apple.backupd[653]: Will copy (Zero KB) from Photo Masters 5
17/11/2014 19:49:26.113 com.apple.backupd[653]: Will copy (Zero KB) from Music and Video
17/11/2014 19:49:26.114 com.apple.backupd[653]: Found 78 files (46.97 GB) needing backup
17/11/2014 19:49:26.128 com.apple.backupd[653]: 58.16 GB required (including padding), 1.24 TB available
17/11/2014 19:49:26.676 com.apple.backupd[653]: Copied 3 items (234 bytes) from volume ScratchUse. Linked 5.
17/11/2014 19:49:28.844 com.apple.backupd[653]: Copied 28 items (110 KB) from volume Macintosh HD. Linked 367.
17/11/2014 19:49:30.535 com.apple.backupd[653]: Copied 1 items (Zero KB) from volume Photo Masters Vol 3. Linked 5.
17/11/2014 19:49:31.428 com.apple.backupd[653]: Copied 1 items (Zero KB) from volume Photo Masters 5. Linked 3.
17/11/2014 19:49:32.180 com.apple.backupd[653]: Copied 1 items (Zero KB) from volume Music and Video. Linked 7.
17/11/2014 19:49:33.202 com.apple.backupd[653]: Created new backup: 2014-11-17-194932
The difference is the files on ScratchUse that had already been backed-up.
If you want to test this, I suggest making sure that you use a disk where the amount used on the disk is less than the free space on your backup drive, otherwise you will lose backups.