I've been having the same problem with my keyboard becoming totally unresponsive, but it's intermittent. Sometimes it works on startup, sometimes it doesn't. I'm using a late 2012 Mac Mini. I do not have the problems some have reported with certain keys not working. The "unplug/plug back in" method only works some of the time. The work around that consistently works is unplugging the usb keyboard from the mac I'm using it on, plug it into ANY other computer to "turn it back on", and then plug it back into the mac I want to use. Major pain in the butt, so I keep an small old PC laptop on my desk so it's handy, Apple really needs to fix this NOW because it's just one of a zillion problems that are making Yosemite unusable in a real world environment. It's TOO glitchy and UNSTABLE to use for anything of importance.
Had no problems at all during beta on several different Macs. Since upgrading to the new release, Ive had nothing but trouble trouble trouble with network connectivity, keyboards unresponsive, usb devices being "forgotten" in the middle of use, software glitches with Apple and non-Apple apps, wake/sleep problems, weird startup glitches. I've completely "clean" reinstalled onto brand new SSD's and even tried reinstalling onto new SATA disks, the problem seems to be Yosemite is just not ready for public consumption and is still loaded with bugs and problems that may be months away from getting fixed. Even on macs where I've kept "everything Apple" and isolated from my other network machines, there are problems, so even a "clean" "all-Apple" installation doesn't work properly. Never experienced such a horrible upgrade on any equipment or operating system in over 30 years. Maybe Yosemite works on the brand new hardware Apple is rolling out, but it doesn't work well enough to get by on their older equipment. If it wasn't such a hassle to revert, I'd go back to Mavericks. At this point, only people who are in a position to "experiment" should be using Yosemite, and I would not recommend that anyone who relies on their computer for important work to upgrade until Yosemite is a viable, working OS. Right now, for far too many of us, it's no where near ready. IT IS STILL VERY MUCH A BETA PRODUCT and should not have been released yet.