Q: Mac Running Slow after Yosemite

I have upgraded this machine but now applications hang.  I have cleared the cache, deleted applications such as Chrome, repaired  permissions and turned off any start up applications.

This is the EtreCheck output.  I am not sure how to read it - are there other items I should delete or amend?  Thanks

EtreCheck version: 2.0.8 (95)

Report generated 30 October 2014 19:21:03 GMT

Hardware Information: ℹ️

  iMac (21.5-inch, Mid 2010) (Verified)

  iMac - model: iMac11,2

  1 3.2 GHz Intel Core i3 CPU: 2-core

  8 GB RAM Upgradeable

  BANK 0/DIMM0

  2 GB DDR3 1067 MHz ok

  BANK 1/DIMM0

  2 GB DDR3 1067 MHz ok

  BANK 0/DIMM1

  2 GB DDR3 1067 MHz ok

  BANK 1/DIMM1

  2 GB DDR3 1067 MHz ok

  Bluetooth: Old - Handoff/Airdrop2 not supported

  Wireless:  en1: 802.11 a/b/g/n

Video Information: ℹ️

  ATI Radeon HD 5670 - VRAM: 512 MB

  iMac 1920 x 1080

System Software: ℹ️

  OS X 10.10 (14A389) - Uptime: 0:16:44

Disk Information: ℹ️

  WDC WD1001FALS-40Y6A0 disk0 : (1 TB)

  S.M.A.R.T. Status: Verified

  EFI (disk0s1) <not mounted> : 210 MB

  Macintosh HD (disk0s2) /  [Startup]: 732.85 GB (85.41 GB free)

  Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB

  BOOTCAMP (disk0s4) /Volumes/BOOTCAMP : 266.49 GB (165.37 GB free)

  OPTIARC DVD RW AD-5680H 

USB Information: ℹ️

  Apple Computer, Inc. IR Receiver

  Apple Inc. Built-in iSight

  Apple Inc. BRCM2046 Hub

  Apple Inc. Bluetooth USB Host Controller

  Apple Internal Memory Card Reader

Gatekeeper: ℹ️

  Mac App Store and identified developers

Kernel Extensions: ℹ️

  /Applications/Karabiner.app

  [not loaded] org.pqrs.driver.Karabiner (10.4.0 - SDK 10.9) Support

  /System/Library/Extensions

  [loaded] com.Cycling74.driver.Soundflower (1.5.2) Support

  [not loaded] com.canon.cups.fax.print.kext.usbprintclass (4.0.0 - SDK 10.5) Support

  [not loaded] com.devguru.driver.SamsungComposite (1.2.44 - SDK 10.6) Support

  /System/Library/Extensions/ssuddrv.kext/Contents/PlugIns

  [not loaded] com.devguru.driver.SamsungACMControl (1.2.44 - SDK 10.6) Support

  [not loaded] com.devguru.driver.SamsungACMData (1.2.44 - SDK 10.6) Support

  [not loaded] com.devguru.driver.SamsungMTP (1.2.44 - SDK 10.5) Support

  [not loaded] com.devguru.driver.SamsungSerial (1.2.44 - SDK 10.6) Support

Startup Items: ℹ️

  HW_CreateNetwork: Path: /Library/StartupItems/HW_CreateNetwork

  HWPortDetect_driver: Path: /Library/StartupItems/HWPortDetect_driver

  Startup items are obsolete and will not work in future versions of OS X

Launch Agents: ℹ️

  [loaded] com.google.keystone.agent.plist Support

  [running] jp.co.canon.CUPSCMFP.BG.plist Support

  [running] jp.co.canon.ScanGearMF.appl.Canon-MF-Scan-Agent.plist Support

  [running] jp.co.canon.UFR2.BG.plist Support

Launch Daemons: ℹ️

  [loaded] com.adobe.fpsaud.plist Support

  [loaded] com.google.keystone.daemon.plist Support

  [loaded] com.macpaw.CleanMyMac2.Agent.plist Support

  [loaded] com.microsoft.office.licensing.helper.plist Support

  [loaded] com.skype.skypeinstaller.plist Support

User Launch Agents: ℹ️

  [loaded] com.adobe.ARM.[...].plist Support

  [running] com.microsoft.LaunchAgent.SyncServicesAgent.plist Support

User Login Items: ℹ️

  Dropbox Application (/Applications/Dropbox.app)

Internet Plug-ins: ℹ️

  Flip4Mac WMV Plugin: Version: 2.4.4.2 Support

  FlashPlayer-10.6: Version: 15.0.0.152 - SDK 10.6 Support

  QuickTime Plugin: Version: 7.7.3

  Flash Player: Version: 15.0.0.152 - SDK 10.6 Mismatch! Adobe recommends 15.0.0.189

  Default Browser: Version: 600 - SDK 10.10

  SharePointBrowserPlugin: Version: 14.4.5 - SDK 10.6 Support

  GarminGpsControl: Version: 2.9.3.0 Release Support

  iPhotoPhotocast: Version: 7.0

User Internet Plug-ins: ℹ️

  Picasa: Version: 1.0 Support

3rd Party Preference Panes: ℹ️

  Flash Player  Support

  Flip4Mac WMV  Support

  Growl  Support

Time Machine: ℹ️

  Skip System Files: NO

  Auto backup: YES

  Volumes being backed up:

  Macintosh HD: Disk size: 732.85 GB Disk used: 647.44 GB

  Destinations:

  Time Capsule [Local]

  Total size: 999.86 GB

  Total number of backups: 43

  Oldest backup: 2014-09-21 13:15:59 +0000

  Last backup: 2014-10-30 18:19:13 +0000

  Size of backup disk: Too small

  Backup size 999.86 GB < (Disk used 647.44 GB X 3)

Top Processes by CPU: ℹ️

      13% mds

      4% com.apple.WebKit.WebContent

      2% WindowServer

      1% Safari

      1% AppleSpell

Top Processes by Memory: ℹ️

  180 MB com.apple.WebKit.WebContent

  146 MB iTunes

  112 MB mds_stores

  103 MB Microsoft Word

  86 MB Safari

Virtual Memory Information: ℹ️

  5.30 GB Free RAM

  2.13 GB Active RAM

  349 MB Inactive RAM

  814 MB Wired RAM

  1.53 GB Page-ins

  0 B Page-outs