This could be related to the old USB2/3 compatibility issue which haunts many USB2 audio related devices...... when using a USB2 device via a USB3 port...
As Pancenter said earlier.. some of these issues are caused by changes made by Apple to provide for better compatibility with older USB2 devices and USB3 ports.. but unfortunately, in my experience... when something is tweaked that fixes things for some devices, other devices that worked ok.. now cease working reliably....
So........
One possible fix is as follows..
Note: Please follow each step exactly in order.... This fix requires the use of a Powered USB2 Hub..... No hub... no fix!
Shut down your Mac
Unplug your USB2 Audio interface..
Reset SMC....
Note: Portable computers that have a battery you should not remove on your own include MacBook Pro (Early 2009) and later, all models of MacBook Air, and MacBook (Late 2009).
- Shut down the computer.
- Plug in the MagSafe power adapter to a power source, connecting it to the Mac if its not already connected.
- On the built-in keyboard, press the (left side) Shift-Control-Option keys and the power button at the same time.
- Release all the keys and the power button at the same time.
- Press the power button to turn on the computer.
Note: The LED on the MagSafe power adapter may change states or temporarily turn off when you reset the SMC.
Now reset PRAM....
A small amount of your computer’s memory, called “parameter random-access memory” or PRAM, stores certain settings in a location that OS X can access quickly. The particular settings that are stored depend on your type of Mac and the types of devices connected to it. The settings include your designated startup disk, display resolution, speaker volume, and other information.
Note: To print these instructions, open Help Viewer’s Action pop-up menu (looks like a gear), then choose Print.
- Shut down your Mac.
- Locate the following keys on the keyboard: Option, Command (⌘), P, and R. You will need to hold these keys down simultaneously in step 4.
- Turn on your Mac.
- Immediately press and hold the Option-Command-P-R keys. You must press this key combination before the gray screen appears.Continue holding the keys down until your Mac restarts, and you hear the startup sound for the second time.
- Release the keys.
- Resetting PRAM may change some system settings and preferences. Use System Preferences to restore your settings.
Now... shut down the Mac one last time...
Connect the USB2 device to a powered USB2 hub and then connect the hub to the USB3 port...
Restart Mac
Delete both the Logic Pro X User and CS prefs
Delete the user preferences
You can resolve many issues by restoring Logic Pro X back to its original settings. This will not impact your media files. To reset your Logic Pro X user preference settings to their original state, do the following:
- In the Finder, choose Go to Folder from the Go menu.
- Type ~/Library/Preferences in the "Go to the folder" field.
- Press the Go button.
- Remove the com.apple.logic10.plist file from the Preferences folder. Note that if you have programmed any custom key commands, this will reset them to the defaults. You may wish to export your custom key command as a preset before performing this step. See the Logic Pro X User Manual for details on how to do this. If you are having trouble with a control surface in Logic Pro X, then you may also wish to delete the com.apple.logic.pro.cs file from the preferences folder.
- If you have upgraded from an earlier version of Logic Pro, you should also remove ~/Library/Preferences/Logic/com.apple.logic.pro.
- Restart the computer.
Now launch Logic Pro X and test.... (and pray!)