Safari always opens with "Welcome to Safari" screen. Home page not saved.

Delete cookies

Safari > Preferences > Privacy > Cookies and other website data:

Press the “Remove All Website Data” button.

It will take a while to finish.

Empty Caches

Safari > Preference > Advanced

Checkmark the box for "Show Develop menu in menu bar".

Develop menu will appear in the Safari menu bar.

Click Develop and select "Empty Caches" from the dropdown.

Turn off Extensions if any, and launch Safari.

Safari > Preferences > Extensions

Turn those extensions one by one and test.

Delete safari .plist file.

Quit all applications. Click on an empty spot on the desktop to activate Finder.

Hold the “Option” key down and click the "Go" menu in the Finder menu bar.

Select “Library” from the drop down.

Library > Preferences > com.apple.Safari.plist

Right click it and select "Move to Trash". Close Finder window.

Please don’t empty the Trash.

Restart. Launch Safari

If this doesn’t help, right click the Trash icon in the Dock and select “Open”.

Right click the com.apple.Safari.plist and select “Put Back”.

Triple-click anywhere in the line below on this page to select it:

~/Library/Preferences/com.apple.Safari.plist

Right-click or control-click the highlighted line and select

Services ▹ Show Info in Finder (or just Show Info)

from the contextual menu.* An Info dialog should open.

☞ Does the dialog show "You can read and write" in the Sharing & Permissions section?

☞ In the General section, is the box labeled Locked checked?

☞ What is the Modified date?

If you don't have read and write access to the item, change the settings as directed here. Note, however, that if one file has wrong access settings, most likely others do as well. If the item is locked, unlock it.

*If you don't see the contextual menu item, copy the selected text to the Clipboard by pressing the key combination command-C. Open a TextEdit window and paste into it (command-V). Select the line you just pasted and continue as above.

This fix worked for me. Thanks!