Q: Will Office 365 work with Voiceover on Mac?

I would be inclined to think this is not the proper place for this question. I would suggest you seek an answer directly from Microsoft. Their accessibility web page can be found at: http://www.microsoft.com/accessibility

It's completely appropriate to ask if Office for Mac will work with VoiceOver.

MBrianWooten, try this resource: http://www.applevis.com/forum/os-x-mac-app-discussion/accessibility-m-s-office-2 016-mac

Good luck!