Dear Bob,
Thank you for the thoughtfulness of your reply and the time you took to write it. I've gone through the list of .kext files in /Systems/Libraries/Extensions, and nothing seems out of place; same with active (running) "extensions". Regarding cache'ing: I get the idea, when it works. I wondered, though, if the slow response I see when starting/switching between applications or processes is because needed files can't be loaded into memory until the cache is cleared by saving updated files to disk. That is, if the memory weren't filled by cached files, it might be available for processes. Perhaps I can monitor that by looking at the swap?
Here is the EtreCheck output (perhaps not as helpful as might be, as just after reboot):
EtreCheck version: 2.1.8 (121)
Report generated March 12, 2015 at 10:19:46 AM EDT
Download EtreCheck from http://etresoft.com/etrecheck
Click the [Click for support] links for help with non-Apple products.
Click the [Click for details] links for more information about that line.
Hardware Information: ℹ️
MacBook Pro (13-inch, Mid 2012) (Technical Specifications)
MacBook Pro - model: MacBookPro9,2
1 2.5 GHz Intel Core i5 CPU: 2-core
4 GB RAM Upgradeable
BANK 0/DIMM0
2 GB DDR3 1600 MHz ok
BANK 1/DIMM0
2 GB DDR3 1600 MHz ok
Bluetooth: Good - Handoff/Airdrop2 supported
Wireless: en1: 802.11 a/b/g/n
Battery Health: Normal - Cycle count 82
Video Information: ℹ️
Intel HD Graphics 4000
Thunderbolt Display 2560 x 1440
System Software: ℹ️
OS X 10.9.5 (13F1066) - Time since boot: 0:4:27
Disk Information: ℹ️
APPLE HDD HTS545050A7E362 disk0 : (500.11 GB)
EFI (disk0s1) <not mounted> : 210 MB
Macintosh HD (disk0s2) / : 499.25 GB (262.97 GB free)
Recovery HD (disk0s3) <not mounted> [Recovery]: 650 MB
HL-DT-ST DVDRW GS41N
USB Information: ℹ️
Apple Inc. FaceTime HD Camera (Built-in)
Apple Inc. BRCM20702 Hub
Apple Inc. Bluetooth USB Host Controller
Apple Inc. Apple Internal Keyboard / Trackpad
Apple Computer, Inc. IR Receiver
Microsoft Microsoft® 2.4GHz Transceiver v7.0
Apple Inc. Apple Thunderbolt Display
Apple Inc. FaceTime HD Camera (Display)
Apple Inc. Display Audio
Thunderbolt Information: ℹ️
Apple Inc. thunderbolt_bus
Apple Inc. Thunderbolt Display
Gatekeeper: ℹ️
Mac App Store and identified developers
Kernel Extensions: ℹ️
/Applications/Karabiner.app
[loaded] org.pqrs.driver.Karabiner (10.6.0 - SDK 10.10) [Click for support]
Launch Agents: ℹ️
[not loaded] com.adobe.AAM.Updater-1.0.plist [Click for support]
[loaded] com.cisco.anyconnect.gui.plist [Click for support]
[loaded] com.oracle.java.Java-Updater.plist [Click for support]
[running] org.macosforge.xquartz.startx.plist [Click for support]
Launch Daemons: ℹ️
[loaded] com.adobe.fpsaud.plist [Click for support]
[running] com.cisco.anyconnect.vpnagentd.plist [Click for support]
[loaded] com.microsoft.office.licensing.helper.plist [Click for support]
[loaded] com.oracle.java.Helper-Tool.plist [Click for support]
[loaded] com.oracle.java.JavaUpdateHelper.plist [Click for support]
[loaded] org.macosforge.xquartz.privileged_startx.plist [Click for support]
User Launch Agents: ℹ️
[loaded] com.adobe.ARM.[...].plist [Click for support]
[loaded] com.adobe.ARM.[...].plist [Click for support]
User Login Items: ℹ️
iTunesHelper Application (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
Karabiner Application (/Applications/Karabiner.app)
RescueTime Application Hidden (/Applications/RescueTime.app)
Internet Plug-ins: ℹ️
AdobeAAMDetect: Version: AdobeAAMDetect 1.0.0.0 - SDK 10.6 [Click for support]
FlashPlayer-10.6: Version: 16.0.0.305 - SDK 10.6 [Click for support]
Default Browser: Version: 537 - SDK 10.9
AdobePDFViewerNPAPI: Version: 11.0.10 - SDK 10.6 [Click for support]
AdobePDFViewer: Version: 11.0.10 - SDK 10.6 [Click for support]
Flash Player: Version: 16.0.0.305 - SDK 10.6 Outdated! Update
QuickTime Plugin: Version: 7.7.3
SharePointBrowserPlugin: Version: 14.4.8 - SDK 10.6 [Click for support]
MeetingJoinPlugin: Version: Unknown - SDK 10.6 [Click for support]
JavaAppletPlugin: Version: Java 8 Update 31 Check version
User internet Plug-ins: ℹ️
WebEx64: Version: 1.0 - SDK 10.6 [Click for support]
Safari Extensions: ℹ️
Searchme [Adware! - Remove]
Slick Savings [Adware! - Remove]
Amazon Shopping Assistant [Adware! - Remove]
Ebay Shopping Assistant [Adware! - Remove]
3rd Party Preference Panes: ℹ️
Flash Player [Click for support]
Java [Click for support]
Spelling [Click for support]
TeXDistPrefPane [Click for support]
Time Machine: ℹ️
Time Machine not configured!
Top Processes by CPU: ℹ️
4% WindowServer
2% Calendar
2% top
1% mdworker
1% X11.bin
Top Processes by Memory: ℹ️
417 MB firefox
253 MB thunderbird
232 MB Things
133 MB com.apple.IconServicesAgent
82 MB mds_stores
Virtual Memory Information: ℹ️
896 MB Free RAM
1.74 GB Active RAM
848 MB Inactive RAM
812 MB Wired RAM
553 MB Page-ins
0 B Page-outs
Diagnostics Information: ℹ️
Mar 12, 2015, 10:15:19 AM /Users/[redacted]/Library/Logs/DiagnosticReports/RescueTime_2015-03-12-101519_[ redacted].crash
Mar 12, 2015, 10:13:36 AM Self test - passed