Drives fail. Often in the first six months, and after that, they may last 5-6 years. Or not. A weak (not just bad) sector block is usually the best indication. Having spare drives on hand should be a must, and rotate primary drives to backup or archive every two years maybe after giving them a long erase - to ease your fears and hopefully find the worst possible error.
RAID6 is useful for holding large video catalogues and projects - and then mirror your RAID6 to another RAID6.
SoftRAID 5 http://www.softraid.com will scan drives in the background for weak blocks, monitor I/O better for read/write errors (without impacting performance is important) and can be well worth its $140 ish price (worth it in tech support alone, too if ever you need it)
A couple programs will write the SMART status to the system log and show the numbers of used and remaining spare blocks. That is something a large study of disk storage revealed. And in today's world, storage needs and the need to "change the light blubs" on a basis before one fails is a must in massive data cloud and big data mining.
Apple's Mac Pro and the RAID card is not "hot swap" capable, though the motherboard in the Classic Mac Pro actually could as designed by Intel. And hot swapping is a handy feature - create a 3 drive mirror array, pull one, you still have two and let SoftRAID do a better rebuild in the background adding a new 3rd mirror drive.
Two drive mirrors are weak and not all that great, in my estimation.
TimeMachine is there to get people to at least have a automatic ish do it and forget it, hopefully, versus none at all. A good beginning. It also turns 8 this September and has slowly, gradually, hopefully, matured. I might buy Disk Warrior 5 if only to check the backup catalogue for integrity though at $99 a waste for most and better spent on another backup drive or something. But you never want to be in need of Data Rescue 4, another $99 product.