I use Matrox DualHead2Go, just updated (4/26/15) to 10.10.3 build (14D136) in a separate partition for testing OS X upgrades, and have not experienced any new problems with the functioning of my dual displays via DualHead2Go on a 2014 MacMini. So at least this build of 10.10.3 is OK with the DualHead2Go.
Note to DerekJames: I use the DualHead2Go instead of using two Mini DisplayPort to DVI adapters plugged to my MacMini because in that configuration it takes the monitors 30 to 90 seconds to be stable. Before stable they will display snow &/or cycle On/Off/On every few seconds as if trying to establish a firm video connection. No such problems exist using the DualHead2Go or using a single monitor (so the DVI adapters are not the problem).
An existing minor problem with the DualHead2Go, under 10.10.2 also, that may be unique to my 2014 MacMini, is that the DualHead2Go does not receive video after Option key is held during restart to select the startup disk. This problem does not exist for my MBookAir (running Mavericks) or any of the other Mac systems tested by Matrox.