Hello Lazo,
From your post it sounds like you have your iCloud account setup in Outlook 2010, but it suddenly will not send whereas your iOS devices are able to send and receive without issue. I would use this section of the following article about troubleshooting iCloud services with Outlook:
Get help using Outlook with iCloud for Windows
If you can't send or receive messages with your iCloud email address, follow these steps:
- Make sure you can send and receive email from iCloud.com and your iOS device.
- Close Outlook.
- Sign out of iCloud for Windows, and then sign back in.
- Restart Outlook.
If you still can't send or receive mail, you can get more help with Outlook or contact us.
Thank you for using Apple Support Communities.
All the best,
Sterling