okay, theposco, maybe I can help you out.
1. yes-probably. Support for the card is built into the OS more than likely
2. yes-everything required should be in the box, and you shouldn't need to buy extra cables (ask the card's seller to make sure)
3. You may.may not not find instructions for this in the box, but the power connectors are easy to find. they are at one end of the logic board closest to the front of yor Mac Pro, about halfway up. 2 8-pin connectors. Bit tricky to get 'em on, but once you do, you're good to go
4. The likelyhood is almost none. I think Apple even support the X2600 and the 8800GT for crying out loud, maybe even the GT120
5.Yes, it's totally safe. Most graphics cards require a power connection of some kind, but that's about it. No addon power supply needed.
Trust me-here there are no obvious or "dumb" questions. We all have to learn somwhere and sometime, and the only way to do that is to find out, get info, and ask questions.
About the only thing I should tell you, theposco, is that with the 2010 Mac Pro, to install a video card, there's this little bar in place. I guess it was put there to stabilize the video card. I couldn't figure out how to get the bar back, to get it to go down and out of the way so I could install a newer video card. Very Annoying. Then I asked a question here, and I found out that there is a button by the fan shroud. If you push that button, then the bar goes back, goes down and out of the way. I wouldn't have known that before. Oh one last thing-if the card has been flashed, or it's a Mac version, you will get a boot screen
but if it's a PC one, it'll work, but you won't see anything until the graphics drivers have been loaded. I think there's a 4 gig version out there, but you have to get it flashed...evga and PNY work fine.
good luck
John B