A start would be to stop using Chrome. That should make a big dent.
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Avoid using any third-party software that claims to clean up your computer. Usually this software does more bad than good. Furthermore, you don't need it. Note that all computers will become slower over time even under normal use. Experienced users typically erase the hard drive and do a clean install from scratch at least once a year or whenever installing a major OS upgrade. Of course doing so also means you must maintain regular and multiple backups.
Add more RAM or cut back on the number of concurrently running applications and utilities. Remove unnecessary software such as anti-malware and software that promises to clean your Mac. Check for runaway processes: Runaway applications can shorten battery runtime, affect performance, and increase heat and fan acti… Also see:
Pre-Mavericks
Open Activity Monitor in the Utilities folder. Select All Processes from the Processes dropdown menu. Click twice on the CPU% column header to display in descending order. If you find a process using a large amount of CPU time (>=70,) then select the process and click on the Quit icon in the toolbar. Click on the Force Quit button to kill the process. See if that helps. Be sure to note the name of the runaway process so you can track down the cause of the problem.
