The itunes6464setup.exe file is a 64-bit installer for a 64-bit application and mainly 64-bit components. The "for older video cards" version mentioned below is a 64-bit installer for a 32-bit application and mainly 32-bit components, similar to all 64-bit versions of iTunes prior to 12.1. It downloads as itunes64setup.exe and may install for you if the new version won't.
For general advice see Troubleshooting issues with iTunes for Windows updates.
The steps in the second box are a guide to removing everything related to iTunes and then rebuilding it which is often a good starting point unless the symptoms indicate a more specific approach.
The further information area has direct links to the current and recent builds in case you have problems downloading, need to revert to an older version, or want to try the iTunes for Windows (64-bit - for older video cards) release as a workaround for performance issues, or for compatibility with QuickTime or third party software on 64-bit systems.
Review the other boxes and the list of support documents further down the page in case one of them applies.
Your library should be unaffected by these steps but there is backup and recovery advice elsewhere in the user tip.
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