Q: My mouse stops working and I loose control of my application, why?

Hi, 1JupiterWarship.  

Thank you for visiting Apple Support Communities.  

I understand your mouse stops working while in use. Does this happen in multiple applications?  Have there been any software or hardware changes to your Mac?  I would start with the troubleshooting steps in the article below as they may help resolve this issue. 

Troubleshooting wireless mouse and keyboard issues

-Jason H.