An interrogation symbol comes up when I turned on my macbook pro and later the main hard drive doesn't show up on utilities

If you open Disk Utility and your hard drive does not appear in the sidebar of Disk Utility, then the drive has failed and must be replaced. Also, see:

If a flashing question mark appears after installing 'OS X Yosemite Recovery Update 1.0.'

A flashing question mark or globe appears when you start your Mac

Question (?) Mark, Blinking Folder, or Gray Screen at Startup

These are related but not identical issues. Their causes are outlined in Intel-based Mac- Startup sequence and error codes, symbols. Solutions may be found in:

A flashing question mark or globe appears when you start your Mac

Mac OS X- Gray screen appears during startup

In most cases the problems may be caused by one or more of these:

a. Problem with the computer's PRAM - See Resetting your Mac's PRAM and NVRAM.

b. Boot drive's directory has been corrupted - Repair with Disk Utility.

c. Critical system files are damaged or deleted - Reinstall OS X.

d. The disk drive is physically non-functional - Replace the hard drive.

Note that the information I have provided is what Apple recommends, If other users suggest different solutions than found here, then be sure what they recommend does not impact on your warranty, if any, or ability to get continuing Apple service.

Please don't start removing drives or changing cables unless you know what you are doing and have exhausted other non-invasive alternatives outlined here. If you perform any work yourself that is unapproved by Apple, then you will void any warranty you may have and lose all further Apple Support.

Repair the Hard Drive and Permissions

Boot from your Snow Leopard Installer disc. After the installer loads select your language and click on the Continue button. When the menu bar appears select Disk Utility from the Utilities menu. After DU loads select your hard drive entry (mfgr.'s ID and drive size) from the the left side list. In the DU status area you will see an entry for the S.M.A.R.T. status of the hard drive. If it does not say "Verified" then the hard drive is failing or failed. (SMART status is not reported on external Firewire or USB drives.) If the drive is "Verified" then select your OS X volume from the list on the left (sub-entry below the drive entry,) click on the First Aid tab, then click on the Repair Disk button. If DU reports any errors that have been fixed, then re-run Repair Disk until no errors are reported. If no errors are reported click on the Repair Permissions button. Wait until the operation completes, then quit DU and return to the installer.

If DU reports errors it cannot fix, then you will need Disk Warrior and/or Tech Tool Pro to repair the drive. If you don't have either of them or if neither of them can fix the drive, then you will need to reformat the drive and reinstall OS X.

The main difference if you are using Lion or Mountain Lion is that you must first boot from the Recovery HD. Simply boot from the Recovery HD to perform the above.

Reinstall Snow Leopard Without Erasing The drive

1. Repair the Hard Drive and Permissions

Boot from your Snow Leopard Installer disc. After the installer loads select your language and click on the Continue button. When the menu bar appears select Disk Utility from the Utilities menu. After DU loads select your hard drive entry (mfgr.'s ID and drive size) from the the left side list. In the DU status area you will see an entry for the S.M.A.R.T. status of the hard drive. If it does not say "Verified" then the hard drive is failing or failed. (SMART status is not reported on external Firewire or USB drives.) If the drive is "Verified" then select your OS X volume from the list on the left (sub-entry below the drive entry,) click on the First Aid tab, then click on the Repair Disk button. If DU reports any errors that have been fixed, then re-run Repair Disk until no errors are reported. If no errors are reported click on the Repair Permissions button. Wait until the operation completes, then quit DU and return to the installer.

If DU reports errors it cannot fix, then you will need Disk Warrior and/or Tech Tool Pro to repair the drive. If you don't have either of them or if neither of them can fix the drive, then you will need to reformat the drive and reinstall OS X.

2. Reinstall Snow Leopard

If the drive is OK then quit DU and return to the installer. Proceed with reinstalling OS X. Note that the Snow Leopard installer will not erase your drive or disturb your files. After installing a fresh copy of OS X the installer will move your Home folder, third-party applications, support items, and network preferences into the newly installed system.

Download and install Mac OS X 10.6.8 Update Combo v1.1.

Reinstalling Lion/Mountain Lion Without Erasing The Drive

Boot to the Recovery HD: Restart the computer and after the chime press and hold down the COMMAND and R keys until the menu screen appears. Alternatively, restart the computer and after the chime press and hold down the OPTION key until the boot manager screen appears. Select the Recovery HD and click on the downward pointing arrow button.

Repair the Hard Drive and Permissions: Upon startup select Disk Utility from the main menu. Repair the Hard Drive and Permissions as follows.

When the recovery menu appears select Disk Utility. After DU loads select your hard drive entry (mfgr.'s ID and drive size) from the the left side list. In the DU status area you will see an entry for the S.M.A.R.T. status of the hard drive. If it does not say "Verified" then the hard drive is failing or failed. (SMART status is not reported on external Firewire or USB drives.) If the drive is "Verified" then select your OS X volume from the list on the left (sub-entry below the drive entry,) click on the First Aid tab, then click on the Repair Disk button. If DU reports any errors that have been fixed, then re-run Repair Disk until no errors are reported. If no errors are reported click on the Repair Permissions button. Wait until the operation completes, then quit DU and return to the main menu.

Reinstall Lion/Mountain Lion: Select Reinstall Lion/Mountain Lion and click on the Continue button.

Note: You will need an active Internet connection. I suggest using Ethernet if possible because it is three times faster than wireless.

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If the Utility Menu from the Recovery HD is what is coming up when you boot the computer, then your hard drive is probably dead. Until you replace it and install the old drive in an external enclosure you won't know if your files are even recoverable. However, at this point there is nothing you can do to recover them until you replace the old drive, install OS X, put the old drive into an external enclosure. Then you can determine if your files are recoverable.

If that is the case, then it suggests that the old drive has failed. I don't know if it's going to be possible to recover your files, but see the following:

General File Recovery

If you stop using the drive it's possible to recover deleted files that have not been overwritten by using recovery software such as MAC Data Recovery, Data Rescue II, File Salvage or TechTool Pro. Each of the preceding come on bootable CDs to enable usage without risk of writing more data to the hard drive. Two free alternatives are Disk Drill and TestDisk. Look for them and demos at MacUpdate or CNET Downloads. Recovery software usually provide trial versions that enable you to determine if the software would help before actually paying for it. Beyond this or if the drive has completely failed, then you would need to send the drive to a recovery service which is very expensive.

The longer the hard drive remains in use and data are written to it, the greater the risk your deleted files will be overwritten.

Also visit The XLab FAQs and read the FAQ on Data Recovery.