I have experienced "Not Responding" freezes with iTunes 12.2.1.16 ever since I installed it a few weeks ago. I have tried uninstalling and reinstalling iTunes. That did not help. I also installed the most recent Microsoft general updates. That didn't do anything either. Please tell me what will fix it. Thank you.
For general advice see Troubleshooting issues with iTunes for Windows updates.
The steps in the second box are a guide to removing everything related to iTunes and then rebuilding it which is often a good starting point unless the symptoms indicate a more specific approach.
Review the other boxes and the list of support documents further down the page in case one of them applies.
The further information area has direct links to the current and recent builds in case you have problems downloading, need to revert to an older version or want to try the iTunes for Windows (64-bit - for older video cards) release as a workaround for installation or performance issues, or compatibility with QuickTime or third party software.
Your library and device backups should be unaffected by these steps but there are also links to backup and recovery advice should it be needed.
If the issue persists and you have a 64-bit system try the for older video cards version which is a 64-bit installer for mostly 32-bit code, similar to all 64-bit versions of iTunes up to 12.1.
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itunes 12.2.1.16 freezes
