My USB mouse isn't working.

Your header says USB mouse; you question talks about a wireless mouse. Which is it and what brand. Have you looked at that brand's forums?

If the wireless mouse is one of those third-party devices with a USB Receiver, that needs to be

plugged into the Mac ports, and is factory-paired with only that mouse, it just may be defective.

And there are wireless keyboards that use a similar module for their captive wi-fi receiver.

So should the mouse no longer work with either computer, and it has a USB wi-fi module receiver

it may be time to look for something else. I was given a kensington optical wireless mouse and

the USB wireless receiver module failed; you cannot buy just this one part to have it work, and as

kensington and other brands with the USB Receiver module are factory paired, they won't just

offer to sell you the defective (or if you lent it to a friend & they lost that receiver) or missing part

by simply matching the frequencies by serial number. They won't.

Without more information, you could have almost anything going on there. However it sounds

like you may have something similar to this other situation. That's why I still use wired mouses.

And prefer to watch old cartoons where they get up after an accident, to live happily ever after. 😝

I don't know anything about the brand but I doubt the basic problem is with the Mac. Why don't you want to re-set the Nvram which is a fairly basic Mac action. Otherwise re-setting the SMC is another option.

Several references online to that brand from about 4 years ago suggest the users

and some reviewers had no issues with either OS X or the existing Wndoz product

at the times of their experience. Of course there are sites for this product line as far

away as japan, with english translation, etc.

Always helps to identify the product going into a conversation. Same with most topics...

ie: I have a motor vehicle that won't start: do I troubleshoot before asking, knowing how?😐