Windows 10 and iPod Nano 5th gen don't play well together

you may need to reset the ipod, drivers are all present, but I am using a classic myself

When you say "reinstalling doesn't help" have you followed the procedure given in turingtest2's user tip on Troubleshooting issues with iTunes for Windows updates to remove all components of prior installations before reinstalling iTunes? Issues with iPod connectivity often stem from an "orphaned"

If you're using a 64-bit edition of Windows, it may also be worth installing the "For older video cards" version of iTunes 12.2.1 (link in the referenced user tip) - ignore the name, this is actually (like all versions of iTunes up to 12.0) the 32-bit application with a 64-bit installer. In some cases this may be more compatible with specific hardware/OS/drivers configurations and work where the "full" 64-bit version of Windows does not.

FWIW, I have 12.2.1 running with both 32- and 64-bit editions of Windows 10, and don't have problems with iPods (2nd, 3rd and 7th gen nanos) being detected and syncing correctly - suggesting that there's no fundamental incompatibility involved. The differences between the 5th and 7th gen nanos shouldn't be significant here - they use near-identical hardware and firmware.

I am using 64-bit Windows since XP, and the first x64 bit version of iTunes onwards

3rd gen nano, 6th gen nano, classic 160gb, touch an old iphone all are recognized fine

I could probably find even older ipods, that are known to work as well

Try rebooting your iPod(s) like I said and see if that helps

"I am using 64-bit Windows since XP, and the first x64 bit version of iTunes onwards"

The "64-bit" versions of iTunes prior to 12.1 are all 32-bit applications with some 64-bit code (mainly the installer). Apple never supported any 64-bit edition of Windows XP (though there were workarounds for this). The last version to support XP/Vista (12.1.2) was very specific regarding its OS support:

• Windows XP SP3 - 32-bit installer only
• Windows Vista, 7 and 8 - 32- and 64-bit installers, plus the "for older video cards" version for some 64-bit systems

I'm not sure of the relevance of this to the OP's question, other than to restate that some users have found the "for older video cards" versions of iTunes 12.1 and later to work on 64-bit editions of Windows where the "full" 64-bit versions do not.

Oops ,,, something got lost in my original post (the new Edge browser in Windows 10 doesn't seem to be 100% reliable with this site). The first paragraph should say:

Issues with iPod connectivity often stem from an "orphaned" driver or service left behind from an earlier iTunes version.

A true x64 version of iTunes is a very recent product, necessitated by larger libraries now that enormous hard disks are widely available

I prefer ALAC, which sounds better on my apple product

I suggest with each new version of Windows / iOS etc that a fresh installed be implemented to prevent problems

Not sure why you need to use some crap registry cleaner, I had had to test itunes with a virtual machine as it was problematic

defect with the sound check and cross fade