I have an early 2009 with a 2 x 2.93 GHz 6-Core upgrade. It is crashing during the night with this report. Any suggestions on what might be causing the problem?

Anonymous UUID: A511EDAD-5183-1C1A-6C7F-1C29691B4B28

Tue Aug 4 03:13:34 2015

*** Panic Report ***

panic(cpu 2 caller 0xffffff80195f8683): "TLB invalidation IPI timeout: " "CPU(s) failed to respond to interrupts, unresponsive CPU bitmap: 0x41, NMIPI acks: orig: 0x0, now: 0x0"@/SourceCache/xnu/xnu-2782.30.5/osfmk/x86_64/pmap.c:2480

Backtrace (CPU 2), Frame : Return Address

0xffffff83bd93bb10 : 0xffffff801952bda1

0xffffff83bd93bb90 : 0xffffff80195f8683

0xffffff83bd93bc20 : 0xffffff80195fe973

0xffffff83bd93bd10 : 0xffffff80195ff645

0xffffff83bd93bd70 : 0xffffff80195ad571

0xffffff83bd93be80 : 0xffffff80195a319c

0xffffff83bd93beb0 : 0xffffff801959f013

0xffffff83bd93bee0 : 0xffffff801956a42d

0xffffff83bd93bf90 : 0xffffff80195c9eb9

0xffffff83bd93bfb0 : 0xffffff80196125b7

BSD process name corresponding to current thread: kernel_task

Mac OS version:

14E46

Kernel version:

Darwin Kernel Version 14.4.0: Thu May 28 11:35:04 PDT 2015; root:xnu-2782.30.5~1/RELEASE_X86_64

Kernel UUID: E3C26B2F-8B97-3F1D-B193-690F7E34F830

Kernel slide: 0x0000000019200000

Kernel text base: 0xffffff8019400000

__HIB text base: 0xffffff8019300000

System model name: MacPro5,1 (Mac-F221BEC8)

System uptime in nanoseconds: 40177507168536

last loaded kext at 794429952657: com.apple.filesystems.smbfs 3.0.1 (addr 0xffffff7f9c4a8000, size 389120)

last unloaded kext at 310378514768: com.apple.filesystems.msdosfs 1.10 (addr 0xffffff7f9c4a8000, size 61440)

loaded kexts:

com.eset.kext.esets_kac 600.01.40f01

com.eset.kext.esets_pfw 600.01.40f01

com.owc.driver.Accelsior 1.0 b2

org.dungeon.driver.SATSMARTDriver 0.8

com.apple.filesystems.smbfs 3.0.1

com.apple.driver.AudioAUUC 1.70

com.apple.driver.AppleHWSensor 1.9.5d0

com.apple.driver.AppleTyMCEDriver 1.0.2d2

com.apple.driver.AGPM 110.19.6

com.apple.driver.AppleOSXWatchdog 1

com.apple.filesystems.autofs 3.0

com.apple.iokit.IOBluetoothSerialManager 4.3.5f8

com.apple.driver.AppleMikeyHIDDriver 124

com.apple.driver.AppleUpstreamUserClient 3.6.1

com.apple.driver.AppleMCCSControl 1.2.12

com.apple.iokit.IOUserEthernet 1.0.1

com.apple.kext.AMDFramebuffer 1.3.2

com.apple.driver.AppleHDA 272.18.1

com.apple.driver.AppleMikeyDriver 272.18.1

com.apple.Dont_Steal_Mac_OS_X 7.0.0

com.apple.AMDRadeonX4000 1.3.2

com.apple.driver.AppleHWAccess 1

com.apple.driver.AppleHV 1

com.apple.iokit.BroadcomBluetoothHostControllerUSBTransport 4.3.5f8

com.apple.driver.AppleLPC 1.7.3

com.apple.kext.AMD7000Controller 1.3.2

com.apple.driver.AppleIntelSlowAdaptiveClocking 4.0.0

com.apple.driver.ACPI_SMC_PlatformPlugin 1.0.0

com.apple.iokit.SCSITaskUserClient 3.7.5

com.apple.AppleFSCompression.AppleFSCompressionTypeDataless 1.0.0d1

com.apple.AppleFSCompression.AppleFSCompressionTypeZlib 1.0.0

com.apple.BootCache 36

com.apple.driver.XsanFilter 404

com.apple.iokit.IOAHCIBlockStorage 2.7.1

com.apple.driver.AppleFWOHCI 5.5.2

com.apple.driver.AppleUSBHub 705.4.2

com.apple.driver.Intel82574L 2.6.8b1

com.apple.driver.AirPort.Brcm4331 800.20.24

com.apple.driver.AppleAHCIPort 3.1.2

com.apple.driver.AppleUSBEHCI 705.4.14

com.apple.driver.AppleUSBUHCI 656.4.1

com.apple.driver.AppleHPET 1.8

com.apple.driver.AppleRTC 2.0

com.apple.driver.AppleACPIButtons 3.1

com.apple.driver.AppleSMBIOS 2.1

com.apple.driver.AppleACPIEC 3.1

com.apple.driver.AppleAPIC 1.7

com.apple.driver.AppleIntelCPUPowerManagementClient 218.0.0

com.apple.nke.applicationfirewall 161

com.apple.security.quarantine 3

com.apple.security.TMSafetyNet 8

com.apple.driver.AppleIntelCPUPowerManagement 218.0.0

com.apple.kext.triggers 1.0

com.apple.iokit.IOSerialFamily 11

com.apple.iokit.IOSurface 97.4

com.apple.driver.DspFuncLib 272.18.1

com.apple.kext.OSvKernDSPLib 1.15

com.apple.iokit.IONDRVSupport 2.4.1

com.apple.iokit.IOAcceleratorFamily2 156.16

com.apple.driver.AppleSMBusController 1.0.13d1

com.apple.iokit.IOBluetoothHostControllerUSBTransport 4.3.5f8

com.apple.iokit.IOBluetoothFamily 4.3.5f8

com.apple.driver.AppleHDAController 272.18.1

com.apple.iokit.IOHDAFamily 272.18.1

com.apple.iokit.IOAudioFamily 203.3

com.apple.vecLib.kext 1.2.0

com.apple.iokit.IOFireWireIP 2.2.6

com.apple.driver.AppleSMBusPCI 1.0.12d1

com.apple.kext.AMDSupport 1.3.2

com.apple.AppleGraphicsDeviceControl 3.10.24

com.apple.iokit.IOGraphicsFamily 2.4.1

com.apple.iokit.IOUSBUserClient 705.4.0

com.apple.iokit.IOSlowAdaptiveClockingFamily 1.0.0

com.apple.driver.AppleSMC 3.1.9

com.apple.driver.IOPlatformPluginLegacy 1.0.0

com.apple.driver.IOPlatformPluginFamily 5.9.1d7

com.apple.driver.CoreStorage 471.30.1

com.apple.driver.AppleUSBHIDKeyboard 176.2

com.apple.driver.AppleHIDKeyboard 176.2

com.apple.iokit.IOUSBHIDDriver 705.4.0

com.apple.iokit.IOSCSIBlockCommandsDevice 3.7.5

com.apple.iokit.IOUSBMassStorageClass 3.7.2

com.apple.driver.AppleUSBMergeNub 705.4.0

com.apple.driver.AppleUSBComposite 705.4.9

com.apple.iokit.IOSCSIMultimediaCommandsDevice 3.7.5

com.apple.iokit.IOBDStorageFamily 1.7

com.apple.iokit.IODVDStorageFamily 1.7.1

com.apple.iokit.IOCDStorageFamily 1.7.1

com.apple.iokit.IOAHCISerialATAPI 2.6.1

com.apple.iokit.IOSCSIArchitectureModelFamily 3.7.5

com.apple.iokit.IOFireWireFamily 4.5.7

com.apple.iokit.IO80211Family 730.60

com.apple.iokit.IONetworkingFamily 3.2

com.apple.iokit.IOAHCIFamily 2.7.5

com.apple.iokit.IOUSBFamily 720.4.4

com.apple.driver.AppleEFINVRAM 2.0

com.apple.driver.AppleEFIRuntime 2.0

com.apple.iokit.IOHIDFamily 2.0.0

com.apple.iokit.IOSMBusFamily 1.1

com.apple.security.sandbox 300.0

com.apple.kext.AppleMatch 1.0.0d1

com.apple.driver.AppleKeyStore 2

com.apple.driver.AppleMobileFileIntegrity 1.0.5

com.apple.driver.AppleCredentialManager 1.0

com.apple.driver.DiskImages 397

com.apple.iokit.IOStorageFamily 2.0

com.apple.iokit.IOReportFamily 31

com.apple.driver.AppleFDEKeyStore 28.30

com.apple.driver.AppleACPIPlatform 3.1

com.apple.iokit.IOPCIFamily 2.9

com.apple.iokit.IOACPIFamily 1.4

com.apple.kec.Libm 1

com.apple.kec.pthread 1

com.apple.kec.corecrypto 1.0

Model: MacPro5,1, BootROM MP51.007F.B03, 12 processors, 6-Core Intel Xeon, 2.93 GHz, 32 GB, SMC 1.39f5

Graphics: AMD Radeon HD 7950, AMD Radeon HD 7950, PCIe, 3072 MB

Memory Module: DIMM 1, 8 GB, DDR3 ECC, 1333 MHz, 0x80AD, 0x484D54333147523742465234432D48392020

Memory Module: DIMM 2, 4 GB, DDR3 ECC, 1333 MHz, 0x80CE, 0x4D33393342353237334348302D5948392020

Memory Module: DIMM 3, 4 GB, DDR3 ECC, 1333 MHz, 0x80AD, 0x484D54313531523742465234432D48392020

Memory Module: DIMM 5, 8 GB, DDR3 ECC, 1333 MHz, 0x80AD, 0x484D54333147523742465234432D48392020

Memory Module: DIMM 6, 4 GB, DDR3 ECC, 1333 MHz, 0x80AD, 0x484D54333531523742465238412D48392020

Memory Module: DIMM 7, 4 GB, DDR3 ECC, 1333 MHz, 0x80AD, 0x484D54313531523742465234432D48392020

AirPort: spairport_wireless_card_type_airport_extreme (0x14E4, 0x8E), Broadcom BCM43xx 1.0 (5.106.98.100.24)

Bluetooth: Version 4.3.5f8 15969, 3 services, 27 devices, 1 incoming serial ports

Network Service: Ethernet 1, Ethernet, en0

PCI Card: AMD Radeon HD 7950, Display Controller, Slot-1

PCI Card: AMD Radeon HD 7950, ATY,HamachiParent, Slot-1

PCI Card: pci1b4b,9230, AHCI Controller, Slot-3

Serial ATA Device: HL-DT-ST DVD-RW GH41N

Serial ATA Device: OWC Mercury Accelsior PCIe SSD, 479.95 GB

Serial ATA Device: TOSHIBA DT01ACA100, 1 TB

Serial ATA Device: TOSHIBA MD04ACA500, 5 TB

Serial ATA Device: Hitachi HUA722010CLA330, 1 TB

Serial ATA Device: HGST HDN724040ALE640, 4 TB

Serial ATA Device: ElitePro Qx2, 9 TB

Serial ATA Device: MARVELL VIRTUALL

USB Device: Keyboard Hub

USB Device: Microsoft Wireless Optical Mouse® 1.00

USB Device: Apple Keyboard

USB Device: AS2105

USB Device: AS2105

USB Device: BRCM2046 Hub

USB Device: Bluetooth USB Host Controller

FireWire Device: built-in_hub, Up to 800 Mb/sec

Thunderbolt Bus: