Q: Is IOS 8.4.1 is active Sync compatible with MS Exchange 2010 ?

Hey Plarkass,

Welcome to Apple Support Communities.

If I understand correctly, you have a device with iOS 8.4.1 and you want to know if it's compatible with Microsoft Exchange ActiveSync 2010. Yes, as stated in the article below iOS supports Microsoft Exchange ActiveSync 2007 and later.

Set up a corporate email server in iOS - Apple Support

iOS supports standard Mail protocols including IMAP, SMTP, and Microsoft Exchange ActiveSync 2007 and later. To learn how to set up iOS devices for use with a corporate email server, see the iOS Deployment Technical Reference Guide.

This article will walk you through the process of setting up the Exchange ActiveSync account on your device.

Set up Exchange ActiveSync on your iPhone, iPad, or iPod touch - Apple Support

Cheers.