Go step by step and test.
1. Delete Caches.db
Close all windows and quit all applications.
Hold "option" key down and click "Go" menu in the Finder menu bar.
Select "Library" from the dropdown.
Library > Caches > com.apple.Safari > Caches.db
Right click the Caches.db file and select "Move To Trash.
Close windows and relaunch Safari.
2. Delete Cookies
Safari > Preferences > Privacy > Cookies and other website data:
Click the “Details” button.
Remove all cookies except ones from Apple, your internet service provider and banks.
3. Safari > Preferences > Extensions
Turn off Extensions if any and launch Safari again to test.
Turn on those one by one and test.
4. Delete com.apple.Safari.plist file and test.
Empty the Trash.
Quit all applications.
Hold the option key down and click the "Go" menu in the Finder menu bar.
Select "Library" from the drop down.
Library > Preferences > com.apple.Safari.plist
Right click on it and select "Move it to Trash".
Restart. Relaunch Safari.
If this doesn’t help, “Put Back” the com.apple.Safari.plist
Right click on the Trash icon in the Dock and select “Open”.
Right click on the com.apple.Safari.plist and select “Put Back”.
If you are using Flash Player:
5. System Preferences > Flash Player > Advanced
Press the "Delete All" button under “Browsing Data and Settings”.