Wired Keyboard and Bluetooth Magic Mouse disconnecting simultaneously and requiring reboot

UPDATE

I have found that disabling WiFi has caused the issue to occur less frequently. I have a bluetooth keyboard as well now. It seems to lose connection at the same time as the mouse, but I hit the spacebar and the keyboard reconnects. The mouse remains unresponsive and the bluetooth icon tends to cycle between the dots, zigzag line and the standard bluetooth logo when I press space (only when I'm having disconnect issues, not during general use)

UPDATE 2

I tried using a wired mouse that i plugged in upon disconnection of the mouse and keyboard. It would not respond either. System still requires a restart for peripherals to start operating properly.

I've given it a go. Just going to test it for a while to see if the problem comes back. Thanks for the help! 🙂

It happened again. Though this time devices recovered. I had a USB flash drive connected at the time and that had been disconnected at the same time as the keyboard and mouse as well.

UPDATE 3

I have found that opening a TeamViewer remote desktop connection and moving the cursor remotely from my other desktop, It can cause the connected splash screen to appear and the devices regain connection. Below I have entered a summary of everything tried so far for future reference of people with similar issues.

Error analysis

• Keyboard and mouse will become unresponsive. The light on the mouse will not illuminate when mouse is picked up. Wired peripherals will also become unresponsive.
• USB devices such as flash drives will unmount.
• The system still runs correctly (Videos will continue to run, audio will still be heard through headphones, clock will continue to update, messages & notifications etc.)
• The only way so far I have found that corrects the issue is to reboot the Mac; for the issue to repeat some short time after. The time it takes for this to occur is seemingly random. It occurs under various system loads and when performing different tasks.
• By going into TeamViewer and connecting remotely to the Mac; I can control the cursor without issue. When waving the cursor for a few seconds via the remote desktop it displays the connected splash screen for both keyboard and mouse. Input devices plugged into the mac also start working as well after moving the cursor via this method.
• I tested a device with an LED indicator on it inside of a USB port. It illuminated so the ports must still be powered when the fault occurs.

Fixes attempted

• Error persists in Yosemite and El Capitan (Issue first appeared on Yosemite)
• I have tried using a clean installation of Yosemite to no avail.
• I have reset the SMC, still no luck.
• This issue began just before I moved house. It has occurred to random severity ever since

Thanks, I've had basic technical training so I'm kinda used to troubleshooting. Just new to Macs.

As for the PRAM, I had spoken to Apple support a few hours ago. Just going to test until the end of the evening and then post results. Thanks for your time! 🙂

UPDATE 4

Well after an evening of testing I hate to say all attempts are still unsuccessful. I'm going to take it to the Apple store at the next possible time. It seems likely that the issue is hardware related (Just hoping it's not a logic board issue) and will need repairs. My hopes are on it needing a new network card and that being the end of this endeavour!

P.S.

I shall inform on what the actual solution was once it has been found for future reference.