Update on my husband's Mac situation:
My husband returned to his client on Monday and he couldn't send mail AGAIN!! But it turned out to not be his Mac's Mail that was the problem. A switch, a piece of networking equipment that controls the flow of data through his client's computer network, was blocking port 465, the SSL SMTP port required by our ISP. The IT guy was completely confused because it should not have been. So we can only guess that someone did an update to the switch around the same time I had upgraded his Mac to El Capitan, which turned on (checked) those "automatically detect and maintain" options in Mail Account preferences. So when he returned to their location and port 465 was blocked, the Mail app changed the SMTP port assignment from 465 to 587, a frequently used SMTP port. By the way, I believe this was unrelated to continuously downloading error that erasing the files out of V3/maildata fixed.
If your ISP tells you to use specific ports for IMAP, UNCHECK those "automatically detect and maintain boxes"!!! The Mac Mail app should not try to change them. If the ports for your ISP aren't working, then you need to debug the problem. In the Mail app, select Window -> Connection Doctor and then click on tje the Show Logs button. Scroll through the list until you find the current date's SMTP log. You may not know what any of those messages mean, but your support person should.
I definitely feel like I have been battling a hydra, but I think for now, I have finally gotten all the heads cut off. By the way, in all of this, I learned about TeamViewer to be able to access my husband's Mac remotely and it works WONDERFULLY! So if you are like me and are called upon to help friends and family members with their technology, consider installing TeamViewer on their devices. They even have apps for handheld devices.