What is an OSXFUSE RUNTIME VERSION MISMATCH?

I have a MacBook Pro and an iMac. I am running OS X 10.11.1 on both. My business requires Windows programs. I am running VMWare Version 8.02 on both machines with Windows 7 Pro on one and Windows 7 Ultimate on the other.

I have purchase two Seagate backup drives--1 is the Personal Cloud 1 TB and the other is a Backup Plus Desktop 5 tb. The letters states that you can back up both Mac and Windows files (although, it apparently requires some kind of NTFS converter.....Paragon appeared).

When I attached the 5 TB Seagate Drive, I started getting an error message as follows: OSXFUSE Runtime Version Mismatch: The OSXFUSE library version this program is using (which program??? no indication) is incompatible with the loaded OSXFUSE KERNEL EXTENSION.

Now--to the question: I seem to be unable to back up my MAC to the Seagate Back Up Plus (or the Personal Cloud). I understand that the virtual machine is nothing more than a file on the OS, and so I normally delete it from Time Machine backup EXCEPT for the first backup that I make. My objectives are as follows:

1. Back up the Entire Mac one time.

2. Thereafter, exclude the Virtual Machine from the Backup and do normal backups of the rest of the Mac.

3. Copy and Save some of the Windows created files (specifically, *.xlxs files) to the same backup drive in a separate folder.

Am I asking for too much? Is there something wrong with my thinking? Is there a better backup system that will allow me to have backups of my Macs, my virtual machines, and some specific and very large windows excel files?