You would need to go to the apps' developers websites and see if there is an uninstaller; generally, if you installed it by dragging it to your Applications folder, you can just drag it to the trash. If the app came with its own installer, then you should use their uninstaller. You could consider erasing your hard drive and reinstalling the OS - obviously, make a back up first or you'll lose all your files. However, that should only be necessary if there are some problems.
Having said that, enough empty space on your hard drive plays a role in slow downs as does not having enough RAM. So, how much empty space do you have and how much RAM is installed? Also, slowdowns can be caused by unnecessary "cleaning" software or AV software - do you either installed?