It is mostly a cosmetic issue with me. But to note, when you slide the slide-adjuster up towards the earbuds, like for instance when you want the earbuds tight to your face while working out, then when you slide the slider back down to the bottom of the cord the longer side of the cord gets caught up in a loop because of the unequal lengths. Then you'll have to unslide it again, pull the longer cord, and then carefully slide the slider back down to the bottom position- a bit of an inconvenience if you ask me. I was expecting a bit more quality from apple for a $250 "memory" device.
Because of the unequal lengths, it hangs dominantly to the right side. I guess it's ok for right handed people, which i am, but then again, i prefer to hold the nano in my left hand.
There's nothing wrong with the sound quality. I actually believe these earbuds sound better then my previous mini's.