Keep it simple. Time Machine to an encrypted volume, either directly-attached or via Time Capsule.
We all get busy, and many of us don't run manual backups as often as we should. Any backups beat no backups. Recent backups beat old backups. Current backups beat recent backups.
Time Machine is built in, works, can be encrypted, and there are folks here that can usually help if something goes sideways. Yes, once in a while TM gets itself tangled or a TM target disk itself gets corrupted or fails, so either performing an occasional Time Capsule archive or having multiple TM disk or Time Capsule targets can help.
Off-site is nice to have, once basic backups are sorted. If the laptop comes and goes to an office or other location, then there's a potential TM offsite backup, if you can configure a disk or a Time Capsule there. It's also possible to rotate TM backups, though disks do tend to get bumped or dropped.
If your network bandwidth is commensurate with your particular volume of data, uploading some or all or just the most critical data can be appropriate, too. A service such as SpiderOak targets folks fond of encryption, for instance. Or get your own hosting and your own storage, AES-encrypt the data, and upload it yourself — if you wanted to write or acquire the necessary scripts, and schedule the scripts to run. (Again, manually triggered backups are only any good when they are reliably used.)
Disk clones don't get you any depth of backup. You get one copy. If your clone had the bad or corrupt file, you're toast. They're also wasteful of disk space, unless you go to a non-bootable compressed-format archive of some sort. (Then you get to figure out how you'll recovery that, if your OS X boot disk is corrupted, or your Mac gets lost or stolen or irreparably damaged.)
It's quite correct that TM isn't directly bootable, but having a local bootable USB key disk is trivial to set up and use, and many of the Mac systems now support Internet Recovery. OS X recovery mechanisms, as well as OS X migrations and upgrades can all source their input data from Time Machine backups. With third-party backup tools or with clones using dd or Disk Utility or other tools, you'll want to determine how to recover that data, and then use it to perform the install or upgrade or migration.
All backups do occasionally fail, and not enough folks test their own recovery path.
If you're not exchanging data with other systems via external device via the particular device, I'd not use FAT or ExFAT. I'd use GPT-partitioned HFS+-formatted disks; native-format OS X disk volumes.
Encrypted internal disks via FileVault 2 and via encrypted external backups — assuming the encryption keys are sufficiently robustly chosen, and are not forgotten — beats having unencrypted backups, particularly if the Mac or the disk gets stolen or (as all hardware eventually becomes) scrapped.
All storage devices eventually and inevitably fail. Application and system upgrades fail. Volumes get corrupted. Keys get forgotten. Mistakes happen. Etc.
Having any backups beats having no backups.