iTunes 12.2.2.25 and iPhone 6S not compatible?

This error has to do with your version of OS X. See these requirements for the latest version of iTunes for Mac.

Mac System Requirements

Hardware:

• Mac computer with an Intel processor
• To play 720p HD video, an iTunes LP, or iTunes Extras, a 2.0GHz Intel Core 2 Duo or faster processor is required
• To play 1080p HD video, a 2.4GHz Intel Core 2 Duo or faster processor and 2GB of RAM is required
• Screen resolution of 1024x768 or greater; 1280x800 or greater is required to play an iTunes LP or iTunes Extras
• Broadband Internet connection to use Apple Music, the iTunes Store, and iTunes Extras
• Apple combo drive or SuperDrive to create audio, MP3, or back-up CDs; some non-Apple CD-RW recorders may also work. Songs from the Apple Music catalog cannot be burned to a CD.

Software:

• OS X version 10.8.5 or later, Apple Music requires OS X version 10.9.5 or later
• 400MB of available disk space
• Apple Music, Apple Music Radio, iTunes in the Cloud, and iTunes Match availability may vary by country
• iTunes Extras require OS X version 10.10.3 or later

iOS9 requires iTunes 12.3 which in turn requires a computer with OSX 10.8.5 or higher. Your update checker only checks for software for the particular OSX you are currently running and you have reached the end of the line as far as it and iTunes are concerned.

Some people were very lucky and when they upgraded a device to iOS9 directly from Apple instead of using iTunes their devices still worked with the older version of iTunes. Needing iTunes 12.3 is standard for iOS9. If any part of your technology system is older than 5 years you need to learn a different mode of operation and read system requirements for each component before making new purchases or upgrading any software. This is simply the way the modern world works where once a device it 6 months old it is already replace by a newer model. Or you can do like me where i use a 14 year old computer but don't have any fancy cellphones (a $10 no-contract), and am very, very patient in doing anything on the Internet. 🙂 If you want to stay up with technology then get used to budgeting $500+ per year for it, including buying a new computer every 8 years or so.

You don't say which model MacBook you have. Some can be upgraded.

Early '08 Macbook is too old. Late '08 can be upgraded to latest.

Where exactly would you draw the line between greediness and too old? Somebody has to at some point and has probably determined a marketing optimization point. Technology companies can make far more money investing effort in new products which will get millions of users in every 6 months spending hundreds to thousands of dollars than investing it in supporting old products for which there is minimal financial return and are only used by a small percentage of the customer base. Oh yes, those of us who are patient and are not trying to play the latest games on high definition screens are willing to put up with slower machines and are annoyed when support drops, but unless there is government requirement about old machine support (very limited at the moment: Vintage and obsolete products - https://support.apple.com/HT201624) we're unlikely to see it and only a vocal few seem upset at the practice.

I have MacBook Pro OSX 10.7.5 Late 2011; iTunes 12.2.2; and a new iPhone 6S iOS9.2 with the same problem of not being able to back up iTunes due to needing a newer version. How do I upgrade the software so I can back up iTunes on my new iPhone 6s? Any advice?

If you read the thread, then you know that you need a newer version of OS X. Once you get that, read the requirements in my earlier post. You need iTunes version 12.3.2 to sync with iPhone with iOS 9.2.

Я понимаю, технология развивается очень быстро, но это просто чистая алчность в моих глазах.+10