First, have a backup. Flaky problems such as this can sometimes be a hardware problem. If Time Machine or some other scheduled backup tool is not running, get that going first, and get backups going. This usually is not a hardware problem, but it can be.
If Safe Mode doesn't clear this... Usual cause for these is add-on software, anti-malware tools or anti-virus tools, performance accelerators or cache cleaners or other enhancements, or there's some application that's consuming excessive system resources. Use Console.app and Activity Monitor.app to look for applications or processes that are very busy, and for repeating blocks of errors. (Much of what Console.app shows can be arcane and scary — can all that can be entirely normal, too. If you decide to post any of that Console.app output here, please post just a single block of the repeating messages, and please check the contents for any sensitive or confidential data before posting. Please don't post more than maybe a hundred lines of text, and don't post long runs of repeating errors.)
If Safe Mode and if removing the add-ons doesn't help here, then download the Etrecheck tool and post — cut-and-paste — the diagnostic report here. Etrecheck has some checks for certain types of hardware errors, and shows a configuration report for the system. Etrecheck tries to avoid posting anything confidential or sensitive, but check before posting. If you want to know what you're using with this tool before trying it, look around the forums for previous discussions and postings from the tool.