limits & patience
https://dev.mysql.com/doc/refman/5.7/en/table-size-limit.html
in the above link L11moon discovered that all you need to open a large Numbers file is patience, in his case it took about an hour. I had a similar issue and my Numbers file took 34 cpu minutes (well over an hour wall time) to open on iMac 5K Retina, 4Ghz i7 with 16Gb. The file has 2 sheets: 49760 rows x AV cols, 4833 rows x AU cols. This is 4 months of data and my project requires at least a 1 year collection so I'll be heading toward 150,000 rows in the first sheet. From what I've discovered it appears that Numbers is limited to 65K rows 256 cols and besides I can't wait an hour or more for the file to open, so I'm looking for another product. Is there a cloud based Numbers version, like Google sheets? If so what are the row x col limits. Not sure about Excel limits either, but I like what I see looking at MySQL - https://dev.mysql.com/doc/refman/5.7/en/table-size-limit.html but that will be a learning curve.
iMac (Retina 5K, 27-inch, Late 2014), OS X El Capitan (10.11.2), Numbers v 3.6.1 (2566)