Setting up again with the (Assist me) > (Assistant) setup "wizard" asks you few questions, inspects your Hardware, and sets meaningful defaults.
Creating a new, named "Location" in the process, allows you to walk away from any previous settings that may have been made, accidentally or on purpose, and store all the new settings together in a basket of settings that can be applied "all at once" by invoking that "location". Especially if you have a different basket of settings in a different you apply from time-to-time, (e.g., Home vs Work) this allows creating all new settings for a completely different setup quickly and easily, and allows switching back and forth with ease just by choosing the different "location".