That error is a response being received from the drive, by Toast. That means that the drive has reported specific class (key) and type (code) error. In this case, involving a class of errors arising with the recording medium, and the specific error being returned is a write error. This means that the write failed. Why the write failed is not returned — neither the drive nor Toast particularly knows that.
Apply the current patches for your version of Toast, if you're not already current. This can fix incompatibilities with specific sorts of recording media and with how certain drives work. There's a lot more variability here both with media and with drives than most folks realize. Try a recording different drive. Try different media — an entirely different brand, preferably. Try an optical-media cleaning disk. Dusty heads can cause these sorts of errors. Definitely try recording at the lowest speed that the device and medium will allow, too.
Then — if the above fails — please report the problem and the specific recording media being used (there can be recording-related settings data present on optical media, data which is intended to help the drive adapt to the specific media), and the specific model of optical drive, to the folks at Roxio.
Defragging disks and tech tools and the rest are probably not relevant here, unfortunately. (I don't recall off-hand if a failure to get data to the disk fast enough — what defragmenting is intended to address — shows as a write error or not, but I wouldn't bet on there being any sane matching with any of the optical device errors. Optical drives are sketchy and semi-unreliable devices in general, no two firmware revisions of optical drives ever respond the same and sometimes not even two drives with the same firmware revision, optical drives get increasingly sketchy with age, and the optical media itself can be marvelously flaky. This from having written more than a little optical-recording software.)