Same problem, manually killing disnoted has solved it for now.
Activity Monitor showed Keychain was hung and long periods of spinning beachball, disnoted was using disproportionate cpu, Force Quit disnoted from within Activity Monitor appears to have immediately resolved all the other hung / non-responsive processes like Keychain.
10.11.6 on a mid-2011 MacBook Air. Thanks to replies who suggested this!
After years of reliable upgrades I've had many problems with both Yosemite and El Capitan with the system becoming non-responsive to the point where I couldn't even start Activity Monitor (don't normally have this running), when it's slow / non-responsive the regular Apple Force Quit never works, it's aways a system-called process not an application I've launched.
Also had numerous odd system hangs on Shut Down (system wouldn't shut down all the way, spinning gear on dark screen, manual power down needed). All intermittent.
Unfortunate as until Yosemite one of the nice things about OS X was its super high stability in comparison to Windows (XP, Vista, 7, 8, 10... every windows there is has troublesome). Ironically, though, in Windows CTRL-ALT-DEL almost always lets me kill a non-responsive Windows process and shut down normally, I rarely have to do a forced power down on Windows! On OS X, since Yosemite and continuing with El Capitan, often have to do this.
I wish Apple would stop the annual major updates of OS X (and soon to be Mac OS) and go back to a two year cycle, focusing more on stability. And introduce a more reliable "interrupt" that like CTRL-ALT-DEL for Task Manager on Windows, *always* bringing up Activity Monitor to force quit any process and pulls Activity Monitor to the front. Even when I can get Activity Monitor up, if my system is sluggish due to a hung process or app, Activity Monitor is slow to respond, and if the spinning beach ball is up, Activity Monitor never responds.